Compact High-Voltage AC Generator with Pulse Transformer for High-Frequency Irreversible Electroporation (H-FIRE)

This paper is focused on a design of high-voltage (HV) generator, which proposed for high-frequency irreversible electroporation (H-FIRE). The generator produces bursts bipolar symmetrical pulses. Most HV sources used cell are based controlled discharge capacitor into resistive load. solution very simple, but it associated with certain risk an uncontrolled the capacitor. We present different type where DC-AC inverter pulse transformer and mentioned eliminated. Our able to deliver variable length from 50 150 μs gap between can be set 0.5 1.5 s. Pulse frequency varied 65 470 kHz output voltage in two ranges 0 1.3 kV or 2.5 kV. Results presented load tissue impedance